Tandem mass spectrometry of novel ether-linked phospholipid analogs of anionic pulmonary surfactant phospholipids

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• 作者：Rachel Fickes ; Dennis R. Voelker ; Karin Zemski Berry and Robert C. Murphy
• 刊名：Rapid Communications in Mass Spectrometry
• 出版年：2016
• 出版时间：30 December 2016
• 年：2016
• 卷：30
• 期：24
• 页码：2601-2606
• 全文大小：1143K
• ISSN：1097-0231

文摘

Structural analogs of the bioactive lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol were synthesized with a xylitol polar head group and both diacyl and diether radyl groups. Mass spectral characterization of xylitol phospholipids (PX) was carried out using collisional activation and high-resolution mass measurements of positive molecular ion species and compared with the phosphatidylglycerol (PG) analogs.