文摘
An efficient method for the α-C–H acryloyloxylation of ketones with α,β-unsaturated carboxylic acids was developed, using copper(I) as a catalyst. The most concise approach to form α-acryloyloxy ketones is through direct oxidative coupling at the α-C(sp3)–H position of ketones. This method gives the products in high yields, and has a wide substrate scope in terms of both ketones and unsaturated carboxylic acids. A copper(I)-catalyzed reaction mechanism is proposed based on the results of control experiments.