Early lymphocyte recovery predicts superior outcomes after unmanipulated haploidentical blood and marrow transplant for acute myeloid leukemia

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• 作者：Qiang Fu ; Lan-Ping Xu ; Xiao-Hui Zhang ; Yu Wang ; Ying-Jun Chang and Xiao-Jun Huang
• 刊名：Clinical Transplantation
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：30
• 期：8
• 页码：954-958
• 全文大小：505K
• ISSN：1399-0012

文摘

We investigated whether early lymphocyte recovery, after unmanipulated haploidentical blood and marrow transplant (HBMT), affected clinical outcomes in 134 patients with acute myeloid leukemia (AML). Lymphocyte recovery was based on the absolute lymphocyte count on day 30 (ALC-30). Patients with high ALC-30 (≥294 cells/μL) had higher overall survival (OS) (77.6% vs 59.7%, P=.020) and higher leukemia-free survival (LFS) (74.6% vs 53.7%, P=.016) than those with low ALC-30 values. Multivariate analysis demonstrated that a high ALC-30 was associated with improved overall survival (HR: 0.443, 95% CI: 0.233–0.841; P=.013) and LFS (HR: 0.499, 95% CI: 0.275–0.906; P=.022). Our results suggest that the ALC-30 can predict a superior outcome after unmanipulated HBMT.