The effects of pioglitazone adjuvant therapy on negative symptoms of patients with chronic schizophrenia: a double-blind and placebo-controlled trial
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- 作者：Negar Iranpour ; Atefeh Zandifar ; Mehdi Farokhnia ; Amirhossein Goguol ; Habibeh Yekehtaz ; Mohammad-Reza Khodaie-Ardakani ; Bahman Salehi ; Sophia Esalatmanesh ; Atefeh Zeionoddini ; Payam Mohammadinejad ; Arefeh Zeinoddini and Shahin Akhondzadeh
- 关键词：pioglitazone ; negative symptoms ; schizophrenia ; thiazolidinedione ; clinical trial
- 刊名：Human Psychopharmacology: Clinical and Experimental
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：2
- 页码：103-112
- 全文大小：291K
- ISSN：1099-1077
文摘
The evident central role of inflammation, oxidative stress, and metabolic derangement in pathophysiology of negative symptoms of schizophrenia has opened new insights into probable pharmacological options for these symptoms. Pioglitazone is an antidiabetic agent with anti-inflammatory and antioxidant properties. In this study, we evaluated the efficacy of pioglitazone as an adjunct to risperidone for reduction of negative symptoms in schizophrenia.