Basic study of soft tissue augmentation by adipose-inductive biomaterial

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• 作者：Masaki Yazawa ; Taisuke Mori ; Yasuhide Nakayama and Kazuo Kishi
• 关键词：adipose ; biomaterial ; augmentation ; soft tissue
• 刊名：Journal of Biomedical Materials Research Part B: Applied Biomaterials
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：103
• 期：1
• 页码：92-96
• 全文大小：540K
• ISSN：1552-4981

文摘

Reconstructive surgery for tumor resection, trauma, and congenital anomaly involves volume augmentation with autologous tissue transfer. However, a healthy region is damaged as a donor site, and the autologous tissue is transferred like a patchwork to the recipient site. We have attempted to induce adipogenesis activity in artificial biomaterial that is injectable with an injection needle for soft tissue augmentation. First of all, the optimal dose of pioglitazone hydrochloride was examined with adipo-precursor cells in terms of the proliferator-activated receptor- mRNA expression levels affected by reagent in vitro. Then, salmon collagen with pioglitazone was adjusted in terms of the dose and the salmon collagen was injected into mouse back using an injection needle in vivo. At 4 weeks after implantation, the pioglitazone collagen gel was substituted by mature adipocytes in comparison with the case for control collagen gel without pioglitazone. These results are indicative of the possibility of promoting adipogenesis using collagen with pioglitazone as an adipose-inductive substance.