Redox- and pH-Responsive Nanogels Based on Thiolated Poly(aspartic acid)

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• 作者：Enikő Krisch ; Lé ; a Messager ; Benjá ; min Gyarmati ; Valé ; rie Ravaine and Andrá ; s Szilá ; gyi
• 关键词：drug delivery system ; inverse miniemulsion ; nanogels ; poly(aspartic acid) ; redox responsive
• 刊名：Macromolecular Materials and Engineering
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：301
• 期：3
• 页码：260-266
• 全文大小：1910K
• ISSN：1439-2054

文摘

Nanogels loaded with fluorescent dextran as a model drug are synthesized by the oxidation induced cross-linking of water soluble redox responsive thiolated poly(amino acid) in miniemulsion without the introduction of any cross-linker molecule. Two types of high energy methods, namely, ultrasonication and high pressure homogenization (HPH), are compared. Dynamic light scattering and transmission electron microscopy measurements confirm that spherical nanogels in 100–150 nm diameter range are prepared successfully by HPH method. Size and surface charge of the nanogels can easily be controlled by environmental pH. The release of encapsulated drug is triggered by the degradation of nanogels in reducing environment due to the cleavage of disulphide bonds.