文摘
In this paper, we construct and evaluate all nonisomorphic Latin hypercube designs with n≤16 runs, the use of which guarantee that the estimates of the first-order effects are uncorrelated with each other and also uncorrelated with the estimates of the second-order effects, in polynomial regression models. The produced designs are evaluated using well-known and popular criteria, and optimal designs are presented in every case studied. An effort to construct nonisomorphic small Latin hypercubes in which only the estimates of the first-order effects are required to be uncorrelated with each other has also been made, and new designs are presented. All the constructed designs, besides their stand-alone properties, are useful for the construction of bigger orthogonal Latin hypercubes with desirable properties, using well-known techniques proposed in the literature. Copyright