Photoactivated Functionizable Tetracarbonyl(phenylpyridine)manganese(I) Complexes as CO-Releasing Molecules: A Direct Suzuki-Miyaura Cross-Coupling on a Thermally Stable CO-RM
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- 作者：Jonathan S. Ward ; Joshua T. W. Bray ; Benjamin J. Aucott ; Conrad Wagner ; Natalie E. Pridmore ; Adrian C. Whitwood ; James W. B. Moir ; Jason M. Lynam and Ian J. S. Fairlamb
- 刊名：European Journal of Inorganic Chemistry
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：2016
- 期：31
- 页码：5044-5051
- 全文大小：1081K
- ISSN：1099-0682c
文摘
A new class of carbon monoxide-releasing molecules (CO-RMs) are reported based on a previously known tetracarbonyl phenylpyridine manganese(I) motif. A pre-functionalized CO-RM undergoes a direct Pd-catalysed Suzuki–Miyaura cross-coupling with phenylboronic acid to give a π-extended three-ring CO-RM. Cross-coupling conditions were modified to allow coupling of a morpholine-containing boronic acid on to a CO-RM, introducing drug-like functionality. An LED system was used to facilitate controlled CO-release. Irradiation using an LED (400 nm or 365 nm) gives rise to faster CO-release, with lower overall input power than traditional use of a TLC lamp (365 nm), as measured by an assay based on the conversion of deoxymyoglobin to carbonmonoxymyoglobin.