Manganese(I)-Catalyzed C−H Activation: The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination
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- 作者：Dr. Nasiru P. Yahaya ; Kate M. Appleby ; Magdalene Teh ; Conrad Wagner ; Erik Troschke ; Joshua T. W. Bray ; Prof. Simon B. Duckett ; L. Anders Hammarback ; Dr. Jonathan S. Ward ; Jessica Milani ; Dr. Natalie E. Pridmore ; Dr. Adrian C. Whitwood ; Dr. Jason M. Lynam and Prof. Ian J. S. Fairlamb
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：September 26, 2016
- 年：2016
- 卷：55
- 期：40
- 页码：12455-12459
- 全文大小：2002K
- ISSN：1521-3773
文摘
Manganese-catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven-membered MnI intermediate is detected and characterized that is effective for H-transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnI by judicious choice of an electron-deficient 2-pyrone substrate containing a 2-pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry.