Nanomaterial Uptake: Fast Targeting and Cancer Cell Uptake of Luminescent Antibody-Nanozeolite Bioconjugates (Small 39/2016)
详细信息 查看全文
- 作者：Riccardo Marega ; Eko Adi Prasetyanto ; Carine Michiels ; Luisa De Cola and Davide Bonifazi
- 刊名：Small
- 出版年：2016
- 出版时间：October 19, 2016
- 年：2016
- 卷：12
- 期：39
- 页码：5369
- 全文大小：2397K
- ISSN：1613-6829
文摘
On page 5431, L. De Cola, D. Bonifazi, and co-workers report the fast targeting and cancer cells uptake of nanozeolite/Cetuximab bioconjugates. The effects are depicted on the front cover, which highlights the antibody-dependent and receptor-mediated endocytosis of this luminescent nanomaterial by the cancer cells. This hasty internalization profile can be exploited to reduce the nanomaterial clearance processes occurring in-vivo, which determine unfavourable biodistribution and foster “off-target” activities.