Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3

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• 作者：Anna R. Reynolds ; Meredith A. Saunders and Mark A. Prendergast
• 刊名：Alcoholism: Clinical and Experimental Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：40
• 期：7
• 页码：1454-1461
• 全文大小：307K
• ISSN：1530-0277

文摘

Prior studies demonstrate that ethanol (EtOH) exposure induces the release of intracellular calcium (CA²⁺) in modulation of γ-aminobutyric acid-ergic tone and produces concomitant alterations in sigma (σ)-1 protein expression that may contribute to the development EtOH dependence. However, the influence of CA²⁺ released from endoplasmic reticulum (ER)-bound inositol triphosphate (IP3) and σ-1 receptors in regulating hippocampal function has yet to be delineated.