Studies on Activity Guided Fractionation of Pomegranate Peel Extracts and Its Effect on Antidiabetic and Cardiovascular Protection Properties

详细信息    查看全文

• 作者：K. B. Arun ; P. Jayamurthy ; C. V. Anusha ; S. K. Mahesh and P. Nisha
• 刊名：Journal of Food Processing and Preservation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：41
• 期：1
• 全文大小：405K
• ISSN：1745-4549

文摘

Pomegranate peel (PP) was sequentially extracted with hexane, ethyl acetate, methanol, methanol/water and water (C1–C5, respectively) and the extracts were assessed for its antioxidant and antidiabetic potential. Extracts, C2 and C3, which exhibited maximum free radical scavenging and α-glucosidase inhibitory activity, were further fractionated using hexane, ethyl acetate and methanol (C2–F1, F2, F3; C3–F4, F5, F6). Fractions, F1 and F5, of methanol extract showed highest 2,2-diphenyl picrylhydrazyl scavenging activity (IC₅₀ – 3.69 and 4.39 µg/mL, respectively); F5 exhibited significantly high 2,2′-azinobis 3-ethylbenzothiazoline 6-sulfonic acid, superoxide and hydroxyl radical scavenging activity (IC₅₀ – 3.6, 20.89 and 10.7 µg/mL) and α-glucosidase inhibition (IC₅₀ – 0.0453 µg/mL). F5 demonstrated promising inhibition against LDL oxidation (IC₅₀ – 16.2 µg/mL) and ACE inhibition properties (IC₅₀ – 0.77 µg/mL). These findings suggest the ability of PP extracts to manage type 2 diabetes and associated complications.