Enantioselective Intramolecular C−H Insertion of Donor and Donor/Donor Carbenes by a Nondiazo Approach

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• 作者：Dong Zhu ; Jun Ma ; Kui Luo ; Hongguang Fu ; Prof. Dr. Li Zhang and Prof. Dr. Shifa Zhu
• 刊名：Angewandte Chemie International Edition
• 出版年：2016
• 出版时间：July 11, 2016
• 年：2016
• 卷：55
• 期：29
• 页码：8452-8456
• 全文大小：876K
• ISSN：1521-3773

文摘

The first enantioselective intramolecular C−H insertion and cyclopropanation reactions of donor- and donor/donor-carbenes by a nondiazo approach are reported. The reactions were conducted in a one-pot manner without slow addition and provided the desired dihydroindole, dihydrobenzofuran, tetrahydrofuran, and tetrahydropyrrole derivatives with up to 99 % ee and 100 % atom efficiency.