Up-regulation of microRNA-491-5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 in human osteosarcoma

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• 作者：Zhixun Yin ; Hongmei Ding ; Erxing He ; Jingchen Chen and Ming Li
• 刊名：Cell Proliferation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：1
• 全文大小：1608K
• ISSN：1365-2184

文摘

MicroRNAs are small non-coding RNAs involved in pathogenesis and progression of human malignancies. MicroRNA-491-5p (miR-491-5p) is down-regulated in many human cancers where it would serve as a tumour suppressor. However, the role played by miR-491-5p in pathogenesis of human osteosarcoma has remained largely unknown. This study has been conducted to examine effects of miR-491-5p on migration and proliferation of cells of the SAOS-2 and MG63 osteosarcoma lines, and mechanisms of those effects.