TGFβ1-Smad3-Jagged1-Notch1-Slug signaling pathway takes part in tumorigenesis and progress of tongue squamous cell carcinoma

详细信息    查看全文

• 作者：Tonghan Zhang ; Lizhong Liang ; Xiaoling Liu ; Ji-nan Wu ; Jueyao Chen ; Kui Su ; Qiaoyi Zheng ; Hongzhang Huang and Gui-qing Liao
• 刊名：Journal of Oral Pathology & Medicine
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：45
• 期：7
• 页码：486-493
• 全文大小：608K
• ISSN：1600-0714

文摘

TGFβ1 and Smad3 play an important role in the process of EMT. TGFβ1 regulates the expression of Jagged1 by modulating Notch signaling. Jagged1 is related to tumor invasion, metastasis, chemotherapy resistance, and tumor immune escape. The aims of this study are to examine deregulation of TGFβ1-Smad3-Jagged1-Notch1-Slug signaling in TSCC and to investigate its roles in TSCC progression.