Asymmetric -Hydroxylation of β-Indanone Esters and β-Indanone Amides Catalyzed by C-2′ Substituted Cinchona Alkaloid Derivatives
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- 作者：Yakun Wang ; Hang Yin ; Hai Qing ; Jingnan Zhao ; Yufeng Wu and Qingwei Meng
- 关键词：Cinchona alkaloid derivatives ; enantioselectivity ; -hydroxylation ; organocatalysis ; synthetic methods
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2016
- 出版时间：March 3, 2016
- 年：2016
- 卷：358
- 期：5
- 页码：737-745
- 全文大小：586K
- ISSN：1615-4169
文摘
The highly catalytic asymmetric -hydroxylation of β-indanone esters and β-indanone amides using peroxide as the oxidant was realized with a new C-2′ substituted Cinchona alkaloid derivatives. The two enantiomers of -hydroxy-β-indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the corresponding -hydroxy-β-indanone esters and -hydroxy-β-indanone amides with up to 99% yield and 98% ee.