Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1 signaling pathway

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• 作者：Ying Shao ; Chuan Lv ; Can Wu ; Yuehong Zhou and Qiuyue Wang
• 刊名：Diabetes/Metabolism Research and Reviews
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：32
• 期：6
• 页码：534-543
• 全文大小：417K
• ISSN：1520-7560

文摘

Silent information regulator 1 (Sirt1) plays a protective role in kidney. Sirt1 suppresses activation of hypoxia-inducible factor-1 alpha (HIF-1α), with MircroRNA-217 (Mir-217) being closely related to Sirt1. The relationship of Sirt1, HIF-1α and Mir-217, however, has never been reported in high glucose cultured rat glomerular mesangial cells (RMCs). Thus, we explored the role of Mir-217 on inflammation and fibrosis in RMCs cultured with high glucose in vitro through Sirt1/HIF-1α signaling pathway.