Metabolizable Ultrathin Bi2Se3 Nanosheets in Imaging-Guided Photothermal Therapy

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• 作者：Hanhan Xie ; Zhibin Li ; Zhengbo Sun ; Jundong Shao ; Xue-Feng Yu ; Zhinan Guo ; Jiahong Wang ; Quanlan Xiao ; Huaiyu Wang ; Qu-Quan Wang ; Han Zhang and Paul K. Chu
• 刊名：Small
• 出版年：2016
• 出版时间：August 10, 2016
• 年：2016
• 卷：12
• 期：30
• 页码：4136-4145
• 全文大小：5805K
• ISSN：1613-6829

文摘

Poly(vinylpyrrolidone)-encapsulated Bi₂Se₃ nanosheets with a thickness of 1.7 nm and diameter of 31.4 nm are prepared by a solution method. Possessing an extinction coefficient of 11.5 L g⁻¹ cm⁻¹ at 808 nm, the ultrathin Bi₂Se₃ nanosheets boast a high photothermal conversion efficiency of 34.6% and excellent photoacoustic performance. After systemic administration, the Bi₂Se₃ nanosheets with the proper size and surface properties accumulate passively in tumors enabling efficient photoacoustic imaging of the entire tumors to facilitate photothermal cancer therapy. In vivo biodistribution studies reveal that they are expelled from the body efficiently after 30 d. The ultrathin Bi₂Se₃ nanosheets have large clinical potential as metabolizable near-infrared-triggered theranostic agents.