Whole cell bioconversion of (+)-valencene to (+)-nootkatone by Yarrowia lipolytica using a three phase partitioning bioreactor

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• 作者：Dulce M Palmerí ; n-Carre&#241 ; o ; Carlos O Castillo-Araiza ; Olga M Rutiaga-Qui&#241 ; ones ; José ; R Verde Calvo ; Gloria M Trejo-Aguilar ; Abhishek Dutta and Sergio Huerta-Ochoa
• 关键词：bioconversion ; partitioning bioreactor ; (+)-nootkatone ; orange essential oil ; yeast ; product inhibition
• 刊名：Journal of Chemical Technology & Biotechnology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：91
• 期：4
• 页码：1164-1172
• 全文大小：646K
• ISSN：1097-4660

文摘

Low permeability of substrates across the cell membrane, cofactor regeneration and product inhibition are some drawbacks of (+)-nootkatone bioconversion. The aim of this work was to evaluate and enhance the bioconversion of (+)-valencene to (+)-nootkatone with Yarrowia lipolytica in a partitioning bioreactor using orange essential oil as the dispersed phase.