Cobalt(II)-Catalyzed C−N Bond Formation: Synthesis of Aryl-Substituted Imidazo[1,2-a]pyridines

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• 作者：Sk. Rasheed ; Desaboini Nageswar Rao and Dr. Parthasarathi Das
• 刊名：Asian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：5
• 期：10
• 页码：1213-1218
• 全文大小：1206K
• ISSN：2193-5815

文摘

A novel protocol for cobalt(II)-catalyzed synthesis of 2-arylimidazo[1,2-a]pyridines and 3-arylimidazo[1,2-a]pyridines by direct C−N bond formation has been developed. This ligand- and base-free oxidative process is regioselective and has good functional group tolerability. This annulation reaction probably involves a Co^II/Co^III catalytic system and uses molecular oxygen (O₂) as terminal oxidant. This cobalt catalyst system is simple and efficient, which holds potential for application in C−N bond formation.