Synthesis, Antimicrobial Evaluations, and DNA Photo Cleavage Studies of New Bispyranopyrazoles

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• 作者：Mohamad Yusuf ; Manvinder Kaur and Harvinder Singh Sohal
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：706-713
• 全文大小：330K
• ISSN：1943-5193

文摘

The bispyranopyrazoles () were synthesized from the reactions of dibenzaldehydes () with 3-methylpyrazole-5-one and malononitrile by refluxing under alcoholic medium. The dibenzaldehydes were obtained from the O-alkylation of 3-hydroxybenzaldehyde with suitable 1,ω-dibromoalkanes under the alkaline conditions in the presence of dry EtOH/DMF. The structures of bisheterocyclics were determined from rigorous analysis of their spectral parameters (IR, ¹H-NMR, ¹³C-NMR, and ESI-MS). The newly prepared compounds were screened for their antimicrobial activity against seven bacterial and five fungal strains. The DNA photo cleavage potential of these compounds was also evaluated by using agarose gel electrophoresis, and bispyranopyrazoles , and exhibited significant level of DNA photocleavage activity.