Age Estimation in Living Egyptians Using Signal Joint T-cell Receptor Excision Circle Rearrangement

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• 作者：Samah F. Ibrahim ; Iman F. Gaballah and Laila A. Rashed
• 刊名：Journal of Forensic Sciences
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：61
• 期：4
• 页码：1107-1111
• 全文大小：499K
• ISSN：1556-4029

文摘

Age estimation is one of the challenges in forensic sciences. There are many techniques to estimate the age. Molecular biology approach is one of these techniques. Signal joint T-cell receptor excision circles gene (sjTRECs), is one of this approach. We aimed to use sjTRECs as a suitable marker for age estimation among Egyptian population. TaqMan qPCR approach was used to quantify sjTREC levels in blood samples obtained from 153 healthy Egyptian individuals ranging from a few weeks to 70 years. Our results showed a significant negative correlation between sjTREC levels and age with p ≤ 0.05. Moreover, the individual's age can be determined through this formula Age = −30.671+ (−5.998Y) (Y is dCtTBP − sjTREC) with standard error ±7.35 years. Within the forensic context, sjTREC' levels can be used to estimate the Egyptian individual's age accurately.