Aggression in non-human vertebrates: Genetic mechanisms and molecular pathways

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• 作者：Florian Freudenberg ; Hector Carreñ ; o Gutierrez ; Antonia M. Post ; Andreas Reif and William H. J. Norton
• 刊名：American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：171
• 期：5
• 页码：603-640
• 全文大小：314K
• ISSN：1552-485X

文摘

Aggression is an adaptive behavioral trait that is important for the establishment of social hierarchies and competition for mating partners, food, and territories. While a certain level of aggression can be beneficial for the survival of an individual or species, abnormal aggression levels can be detrimental. Abnormal aggression is commonly found in human patients with psychiatric disorders. The predisposition to aggression is influenced by a combination of environmental and genetic factors and a large number of genes have been associated with aggression in both human and animal studies. In this review, we compare and contrast aggression studies in zebrafish and mouse. We present gene ontology and pathway analyses of genes linked to aggression and discuss the molecular pathways that underpin agonistic behavior in these species.