Anxiety Patients Show Reduced Working Memory Related dlPFC Activation During Safety and Threat

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• 作者：Nicholas L. Balderston ; Katherine E. Vytal ; Katherine O'Connell ; Salvatore Torrisi ; Allison Letkiewicz ; Monique Ernst and Christian Grillon
• 刊名：Depression and Anxiety
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 页码：25-36
• 全文大小：2229K
• ISSN：1520-6394

文摘

Anxiety patients exhibit deficits in cognitive tasks that require prefrontal control of attention, including those that tap working memory (WM). However, it is unclear whether these deficits reflect threat-related processes or symptoms of the disorder. Here, we distinguish between these hypotheses by determining the effect of shock threat versus safety on the neural substrates of WM performance in anxiety patients and healthy controls.