IL23R gene polymorphism with juvenile idiopathic arthritis and its association with serum IL-17A
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- 作者：Samira Emami ; Vahid Ziaee ; Arezou Rezaei ; Maryam Sadr ; Marzieh Maddah ; Ali Akbar Amirzargar and Nima Rezaei
- 刊名：International Journal of Rheumatic Diseases
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：19
- 期：11
- 页码：1189-1196
- 全文大小：170K
- ISSN：1756-185X
文摘
Interleukin 23 (IL-23) and its receptor (IL-23R) seem to play a major role in differentiation of CD4+ T cells into Th17 cells, induction of IL-17 production, and activation of inflammatory pathways. Recent studies have suggested the association of IL-23R polymorphisms with bone and articular inflammation in diseases such as ankylosing spondylitis and rheumatoid arthritis. The aim of this study was to determine the association between IL-23R polymorphisms and juvenile idiopathic arthritis (JIA).