Bactericidal antibiotics promote reactive oxygen species formation and inflammation in human sinonasal epithelial cells
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- 作者：Michael A. Kohanski ; Anuj Tharakan ; Andrew P. Lane and Murugappan Ramanathan Jr.
- 关键词：antibiotics ; ROS ; rhinosinusitis ; TNF ; innate immunity ; inflammasome
- 刊名：International Forum of Allergy & Rhinology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：6
- 期：2
- 页码：191-200
- 全文大小：760K
- ISSN：2042-6984
文摘
Bactericidal antibiotics have been shown to stimulate reactive oxygen species (ROS) formation in mammalian cells through mitochondrial dysfunction. This results in oxidative tissue damage that may have negative consequences for long-term antibiotic use. Antibiotics are widely and heavily used in the treatment of acute and chronic sinusitis; however, the relationship between antibiotics and ROS formation in sinonasal epithelial cells (SNECs) has not yet been demonstrated.