Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni

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• 作者：Dr. Sylvain Clè ; de ; Noemi Cowan ; Dr. Franç ; ois Lambert ; Dr. Hé ; lè ; ne C. Bertrand ; Dr. Riccardo Rubbiani ; Dr. Malay Patra ; Jeannine Hess ; Dr. Christophe Sandt ; Dr. Nicolas Trcera ; Prof. Dr. Gilles Gasser ; Prof. Dr. Jennifer Keiser and Prof. Dr. Clotilde Policar
• 刊名：ChemBioChem
• 出版年：2016
• 出版时间：June 2, 2016
• 年：2016
• 卷：17
• 期：11
• 页码：1004-1007
• 全文大小：482K
• ISSN：1439-7633

文摘

An organometallic derivative of praziquantel was studied directly in worms by using inductively coupled plasma-mass spectrometry (ICP-MS) for quantification and synchrotron-based imaging. X-ray fluorescence (XRF) and IR absorption spectromicroscopy were used for the first time in combination to directly locate this organometallic drug candidate in schistosomes. The detection of both CO (IR) and Cr (XRF) signatures proved that the Cr(CO)₃ core remained intact in the worms. Images showed a preferential accumulation at the worm's tegument, consistent with a possible targeting of the calcium channel but not excluding other biological targets inside the worm.