Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura

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• 作者：M. Le Besnerais ; J. Favre ; C. V. Denis ; P. Mulder ; J. Martinet ; L. Nicol ; H. Levesque ; A. Veyradier ; A. Kopić ; D. G. Motto ; P. Coppo ; V. Richard and Y. Benhamou
• 刊名：Journal of Thrombosis and Haemostasis
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：14
• 期：10
• 页码：1917-1930
• 全文大小：1632K
• ISSN：1538-7836

文摘

Cardiac alterations represent a major cause of mortality in patients with thrombotic thrombocytopenic purpura (TTP). Endothelial injury remains poorly defined, but seems to be a key initiating event leading to the formation of platelet-rich thrombi in TTP patients.