One-Pot Ligation-Oxidative Deselenization at Selenocysteine and Selenocystine
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- 作者：Dr. Nicholas J. Mitchell ; Dr. Sameer S. Kulkarni ; Dr. Lara R. Malins ; Siyao Wang and Prof. Dr. Richard J. Payne
- 刊名：Chemistry - A European Journal
- 出版年：2017
- 出版时间：January 18, 2017
- 年：2017
- 卷：23
- 期：4
- 页码：946-952
- 全文大小：1758K
- ISSN：1521-3765
文摘
The use of native chemical ligation at selenocysteine (Sec) residues with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for accessing native peptides with serine in place of Sec at the ligation junction. The efficiency of both variants of the one-pot ligation–oxidative deselenization chemistry is probed through the synthesis of a MUC5AC-derived glycopeptide.