Single shot three-dimensional pulse sequence for hyperpolarized ¹³C MRI

详细信息    查看全文

• 作者：Jiazheng Wang ; Alan J. Wright ; De-en Hu ; Richard Hesketh and Kevin M. Brindle
• 刊名：Magnetic Resonance in Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：2
• 页码：740-752
• 全文大小：3709K
• ISSN：1522-2594

文摘

Metabolic imaging with hyperpolarized ¹³C-labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single-shot three-dimensional (3D) imaging sequence and demonstrate its capability to generate ¹³C MR images in tumor-bearing mice injected with hyperpolarized [1-¹³C]pyruvate.