Foscarnet, zidovudine and dolutegravir combination efficacy and tolerability for late stage HIV salvage therapy: A case-series experience

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• 作者：Tristan Delory ; Emmanuelle Papot ; Christophe Rioux ; Charlotte Charpentier ; Claire Auge-Courtoi ; Florence Michard ; Gilles Peytavin ; Diane Descamps ; Sophie Matheron and Yazdan Yazdanpanah
• 关键词：HIV ; HIV-2 ; salvage therapy ; dolutegravir ; foscarnet ; zidovudine
• 刊名：Journal of Medical Virology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：88
• 期：7
• 页码：1204-1210
• 全文大小：119K
• ISSN：1096-9071

文摘

Salvage therapy including foscarnet (PFA), zidovudine (ZDV) and an optimized background ART (OBT) has been shown to be effective in patients with advanced HIV infection, and no therapeutic options. Dolutegravir (DTG) may offer a more active combination. Objective was to describe efficacy and tolerability of PFA–ZDV–DTG containing regimen. In our cohort, we identified patients who: (i) had plasma HIV-1 RNA load (pVL) >50 c/ml (>100 for HIV-2) on combination ART (cART); (ii) had at least 1 PI/r, 1 NRTI, 1 NNRTI (for HIV-1), and at least 1 raltegravir resistance mutations; (iii) were naive to DTG; and (iv) initiated on a PFA–ZDV–DTG containing-regimen with 48 weeks (W48) of follow-up. Out of 5 patients, 2 were infected with HIV-2. At PFA–ZDV–DTG initiation, CD4 cell count was (/mm³) of 64, 40, 10, in HIV-1, and 37, 199, in HIV-2 infected patients; and pVL (log₁₀ c/ml) of 4.8, 5.1, 4.4, in HIV-1, and 3.6, 4.2, in HIV-2 infected patients, respectively. Median OBT genotypic sensitivity score was 1.5 [1–2]. PFA was discontinued in one patient, due to an acute renal failure. At W48, one HIV-1 infected patient had a pVL <50 c/ml and two <200 c/ml; the two HIV-2 infected patients had pVL >100 c/ml. No lack of treatment adherence was observed. In treatment experienced HIV-infected patients, failing cART and without other therapeutic options, a PFA–ZDV–DTG combination therapy could be effective. Renal adverse events should be monitored. J. Med. Virol. 88:1204–1210, 2016.