Biexponential longitudinal relaxation in white matter: Characterization and impact on T1 mapping with IR-FSE and MP2RAGE

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• 作者：James A. Rioux ; Ives R. Levesque and Brian K. Rutt
• 刊名：Magnetic Resonance in Medicine
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：75
• 期：6
• 页码：2265-2277
• 全文大小：1807K
• ISSN：1522-2594

文摘

Magnetization transfer in white matter (WM) causes biexponential relaxation, but most quantitative T₁ measurements fit data assuming monoexponential relaxation. The resulting monoexponential T₁ estimate varies based on scan parameters and represents a source of variation between studies, especially at high fields. In this study, we characterized WM T₁ relaxation and performed simulations to determine how to minimize this deviation.