Design of Highly Stable Echogenic Microbubbles through Controlled Assembly of Their Hydrophobin Shell
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- 作者：Dr. Lara Gazzera ; Dr. Roberto Milani ; Dr. Lisa Pirrie ; Dr. Marc Schmutz ; Christian Blanck ; Prof. Giuseppe Resnati ; Prof. Pierangelo Metrangolo and Dr. Marie Pierre Krafft
- 刊名：Angewandte Chemie
- 出版年：2016
- 出版时间：August 22, 2016
- 年：2016
- 卷：128
- 期：35
- 页码：10419-10423
- 全文大小：1782K
- ISSN：1521-3757
文摘
Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.