Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system
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- 作者：Sara M Badenes ; Tiago G Fernandes ; Clá ; udia C Miranda ; Annette Pusch-Klein ; Simone Haupt ; Carlos AV Rodrigues ; Maria Margarida Diogo ; Oliver Brü ; stle and Joaquim MS Cabral
- 刊名：Journal of Chemical Technology and Biotechnology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：92
- 期：3
- 页码：492-503
- 全文大小：1774K
- ISSN：1097-4660
文摘
Human induced pluripotent stem (hiPS) cells provide a fascinating tool for exploring disease mechanisms, compound screening in pharmaceutical drug development, and might also represent a renewable source of cells for regenerative medicine applications. This requires increased cell quantities, generated under Good Manufacturing Practice-compatible conditions in a scalable system.