Inside Cover: Synthesis of Nω-Phospho-class="smallCaps">l-arginine by Biocatalytic Phosphorylation of class="smallCaps">l-Arginine (ChemCatChem 1/2017)
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- 作者：Dr. Bernhard Schoenenberger ; Agata Wszolek ; Thomas Milesi ; Dr. Henrike Brundiek ; Dr. Markus Obkircher and Dr. Roland Wohlgemuth
- 刊名：ChemCatChem
- 出版年：2017
- 出版时间：January 9, 2017
- 年：2017
- 卷：9
- 期：1
- 页码：2
- 全文大小：3789K
- ISSN：1867-3899
文摘
The Cover picture is an artistic view of the highly selective Nω-phosphorylation of L-arginine catalyzed by arginine kinase.In their Full Paper, B. Schoenenberger et al. demonstrate that a highly active and stable arginine kinase, prepared by cloning and expressing the gene for ArgK from Limulus polyphemus in E. coli, ATP-regeneration using the phosphoenolpyruvate/pyruvate kinase system and reaction monitoring by 31P-NMR enable the development of a convenient method for the biocatalytic Nω-phosphorylation of L-arginine. Our results show that tedious multi-step chemical procedures for the synthesis of Nω-phospho-L-arginine can be simplified by a straightforward and highly efficient one-step arginine kinase-catalyzed phosphorylation of L-arginine. More information can be found in the Full Paper by B. Schoenenberger et al. on page 121 in Issue 1, 2017 (DOI: cctc.201601080" rel="references:https://doi.org/10.1002/cctc.201601080">10.1002/cctc.201601080).