The independent predictors of non-alcoholic steatohepatitis and its individual histological features. : Insulin resistance, serum uric acid, metabolic syndrome, alanine aminotransferase and serum total cholesterol are a clue to pathogenesis and candidate targets for treatment

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• 作者：Stefano Ballestri ; Fabio Nascimbeni ; Dante Romagnoli and Amedeo Lonardo
• 刊名：Hepatology Research
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：46
• 期：11
• 页码：1074-1087
• 全文大小：362K
• ISSN：1872-034X

文摘

The diagnosis of non-alcoholic steatohepatitis (NASH) is based on the individual histological features: steatosis, lobular inflammation and ballooning. Non-alcoholic fatty liver disease (NAFLD) activity score (NAS ≥ 5) is used in clinical trials. Fibrosis dictates long-term NAFLD prognosis. Recently, more-than-mild portal inflammation has raised interest as a marker of NAFLD severity. We assessed the independent predictors of: (I) individual histological lesions of NASH; (II) diagnosis of NASH; (III) significant (stage ≥2) and advanced (stage ≥3) fibrosis; and (IV) more-than-mild portal inflammation.