Plasma hyaluronic acid level as a prognostic and monitoring marker of metastatic breast cancer
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- 作者：Cike Peng ; Markus Wallwiener ; Anja Rudolph ; Katarina Ćuk ; Ursula Eilber ; Muhabbet Celik ; Caroline Modugno ; Andreas Trumpp ; Jö ; rg Heil ; Frederik Marmé ; Dharanija Madhavan ; Juliane Nees ; Sabine Riethdorf ; Sarah Schott ; Christof Sohn ; Klaus Pantel ; Andreas Schneeweiss ; Jenny Chang-Claude ; Rongxi Yang and Barbara Burwinkel
- 关键词：metastatic breast cancer ; hyaluronic acid ; prognosis ; plasma ; biomarker
- 刊名：International Journal of Cancer
- 出版年：2016
- 出版时间：May 15 2016
- 年：2016
- 卷：138
- 期：10
- 页码：2499-2509
- 全文大小：540K
- ISSN：1097-0215
文摘
Conventional tumor markers have limited value for prognostication and treatment monitoring in metastatic breast cancer (MBC) patients and novel circulating tumor markers therefore need to be explored. Hyaluronic acid (HA) is a major macropolysaccharide in the extracellular matrix and is reported to be associated with tumor progression. In our study, we investigated plasma HA level with respect to progression free survival (PFS) and overall survival (OS), as well as the treatment monitoring value in MBC patients. The prognostic value of plasma HA level was investigated in a discovery cohort of 212 MBC patients with 2.5-year follow-up and validated in an independent validation cohort of 334 patients with 5-year follow-up. The treatment monitoring value of plasma HA level was investigated in 61 MBC patients from discovery cohort who had been radiographically examined after first complete cycle of chemo therapy. We found a robust association between high plasma HA level and poor prognosis of MBC patients in both discovery (p<sub>PFSsub> = 7.92 × 10<sup>−6sup> and p<sub>OSsub> = 5.27 × 10<sup>−5sup>) and validation studies (p<sub>PFSsub> = 3.66 × 10<sup>−4sup> and p<sub>OSsub> = 1.43 × 10<sup>−4sup>). In the discovery cohort, the plasma HA level displayed independent prognostic value after adjusted for age and clinicopathological factors, with respect to PFS and OS. Further, the decrease of plasma HA level displayed good concordance with treatment response evaluated by radiographic examination (AUC = 0.79). Plasma HA level displays prognostic value, as well as treatment monitoring value for MBC patients.