Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy

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• 作者：Yan Li ; Ruilong Zhang ; Zhiguo Lu ; Guanghui Ma ; Lei Chen ; Qunwei Tang and Xin Zhang
• 刊名：Small
• 出版年：2016
• 出版时间：October 26, 2016
• 年：2016
• 卷：12
• 期：40
• 页码：5516-5523
• 全文大小：2057K
• ISSN：1613-6829

文摘

Three-pronged nanoparticles (NPs) that can efficiently prohibit the proliferation of large tumor are developed for inoperable large tumor therapy. The NPs achieve spatially and temporally controlled release of drugs in target sites. The NPs induce the apoptosis of differentiated cancer cells, cancer stem cells, and vascular niches simultaneously. Importantly, the three-pronged NPs inhibit the growth of large tumors without recurrence.