Salicylic acid (SA)-eluting bone regeneration scaffolds with interconnected porosity and local and sustained SA release

详细信息    查看全文

• 作者：Weiling Yu ; Jennifer Bajorek ; Sayeli Jayade ; Alyssa Miele ; Javad Mirza ; Sarah Rogado ; Aravind Sundararajan ; Jonathan Faig ; Loï ; c Ferrage and Kathryn E. Uhrich
• 刊名：Journal of Biomedical Materials Research Part A
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：105
• 期：1
• 页码：311-318
• 全文大小：409K
• ISSN：1552-4965

文摘

In previous work, we observed that localized and sustained delivery of an anti-inflammatory drug, salicylic acid (SA), via a SA-based polymer (SAP) powder significantly enhanced diabetic bone regeneration through long-term mitigation of local inflammation. In this study, SAP was formulated into uniform microspheres and then sintered into a scaffold with an interconnected porous structure and modulus suitable for bone regeneration. The SAP scaffolds have ∼45% SA loading, which is the highest among drug-eluting bone regeneration scaffolds to-date. In addition, the scaffold provides localized, controlled and sustained SA release that has been proven to enhance diabetic bone regeneration. With the combination of physical (interconnected porosity) and chemical therapeutic features (high drug loading and sustained release), the novel SAP scaffolds offer unique therapeutic advantages and are promising diabetic bone regeneration candidates.