Risk of hypertensive disorders in pregnancy following assisted reproductive technology: overview and meta-analysis

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• 作者：Costas Thomopoulos ; George Salamalekis ; Konstantinos Kintis ; Iliana Andrianopoulou ; Helena Michalopoulou ; George Skalis ; Stefanos Archontakis ; Ourania Argyri ; Costas Tsioufis ; Thomas K. Makris and Emmanuel Salamalekis
• 刊名：The Journal of Clinical Hypertension
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：2
• 页码：173-183
• 全文大小：416K
• ISSN：1751-7176

文摘

The extent of the increased risk of pregnancy hypertensive disorders following assisted reproductive technology (ART) was investigated. PubMed and the Cochrane Collaboration Library were used as data sources to identify and select longitudinal cohorts comparing pregnancies following ART with spontaneously conceived pregnancies, between 1978 and June 2016. Risk ratios and 95% confidence intervals (CIs) of three outcomes, ie, gestational hypertension (GH), preeclampsia (PE), and their sum (PHD), were calculated. Stratification of results by gestation order (singletons and nonsingletons) was pursued, but a separate “all orders” mixed stratification was considered. Sixty-six longitudinal studies (7 038 029 pregnancies; 203 375 following any ART) were eligible. All outcomes independent of gestation order (“all orders”) were increased following any invasive ART: GH (+79% [95% CI, 24%–157%]) and PE (+75% [95% CI, 50%–103%]) to a greater extent, with smaller increases in PHD (+54% [95% CI, 39%–70%]). The risk of PHD following ART steadily increased independent of gestation order.