Ruthenium(II)- or Rhodium(III)-Catalyzed Grignard-Type Addition of Indolines and Indoles to Activated Carbonyl Compounds
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- 作者：Hyeim Jo ; Jihye Park ; Miji Choi ; Satyasheel Sharma ; Mijin Jeon ; Neeraj Kumar Mishra ; Taejoo Jeong ; Sangil Han and In Su Kim
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2016
- 出版时间：September 1, 2016
- 年：2016
- 卷：358
- 期：17
- 页码：2714-2720
- 全文大小：1927K
- ISSN：1615-4169
文摘
The ruthenium(II)- or rhodium(III)-catalyzed pyrimidinyl-directed Grignard-type C−H additions of N-heterocycles with activated aldehydes and ketones are described. A cationic ruthenium catalyst and sodium acetate additive in dichloroethane as solvent were found to be optimal catalytic system for the construction of C-7 alkylated indolines. In sharp contrast, a cationic rhodium complex allows the generation of C-2 alkylated indoles and pyrroles as well as C-1 alkylated carbazoles. The site-selective C−H functionalization of these heterocyclic scaffolds could be an important asset towards the development of novel bioactive compounds.