A monodisperse drug delivery nanostructure based on a polyhedral borane scaffold, featuring diagnostic and targeting functionalities, delivers high-payload of the anticancer agent Chlorambucil selectively to cancer cells, mediated through GLUT-1 receptors. This results in enhanced cytotoxicity compared to the non-targeted parent drug. Furthermore, it was found to localize in the mitochondria of the cell rather than in the nucleus, raising hopes for combating drug resistance associated with Chlorambucil. More information can be found in the Full Paper by M. F. Hawthorne et al. on
page 12715.