Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing

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• 作者：Katharina T. Weiß ; Matthias Fante ; Gudrun Kö ; hl ; Julia Schreml ; Frank Haubner ; Marina Kreutz ; Sonja Haverkampf ; Mark Berneburg and Stephan Schreml
• 刊名：Experimental Dermatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：26
• 期：2
• 页码：127-132
• 全文大小：432K
• ISSN：1600-0625

文摘

Dysregulation of pH is a feature of both tumor growth and tissue repair. In tumors, microenvironmental changes, like in lactate metabolism, lead to altered intra- and extracellular pH (pH_i, pH_e) and vice versa. In wounds, barrier disruption results in extensive variations in pH_e on the wound surface. It is known that altered extracellular proton concentrations have a major impact on cell turnover and migration as well as on the metabolic activity of cells involved in tumor spread and wound closure. The proton-sensing G protein-coupled receptors (GPCRs) GPR4, GPR65 (TDAG8), GPR68 (OGR1) and GPR132 (G2A) are activated via a decrease in pH_e and transduce this signal to molecular intracellular pathways. Based on the current knowledge, we speculate on the role of proton-sensing GPCRs in wound healing and on their potential as mechanistic linkers of tumor growth and tissue repair.