Denosumab-associated hypocalcaemia: incidence, severity and patient characteristics in a tertiary hospital setting

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• 作者：Andrew Liem Hieu Huynh ; Scott Thomas Baker ; Andrew James Stewardson and Douglas Forsyth Johnson
• 刊名：Pharmacoepidemiology and Drug Safety
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：25
• 期：11
• 页码：1274-1278
• 全文大小：75K
• ISSN：1099-1557

文摘

Denosumab-associated hypocalcaemia (DAH) has been reported in patients with osteoporosis or metastatic bone disease and is associated with stages 4 and 5 chronic kidney disease (CKD, estimated glomerular filtration rate <30 mL/min/1.73m²). Other risk factors for hypocalcaemia have not been fully elucidated.