An Easy Access to Construct Some Fused 1,2,4-Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation

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• 作者：Wafaa S. Hamama ; Ghada G. El-Bana ; Saad Shaaban ; O. M. O. Habib and Hanafi H. Zoorob
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：422-428
• 全文大小：737K
• ISSN：1943-5193

文摘

The chemical reactivity of 4-amino-6-benzyl-3-mercapto-1,2,4-triazine-5(4H)-one () towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1,3,4-thiadiazoles , which incorporating 1,2,4-triazine nucleus was achieved. Moreover, compound was subjected to react either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole and , or thiadiazine . However, the tetracyclic ring system was furnished through condensation reaction of isatine with triazine . In addition, some of the new synthesized compounds were evaluated as an antioxidant and antitumor agents.