Metal-Free Synthesis of Highly Substituted Pyridines by Formal [2+2+2] Cycloaddition under Mild Conditions
详细信息 查看全文
- 作者：Dr. Lan-Gui Xie ; Saad Shaaban ; Dr. Xiangyu Chen and Prof. Dr. Nuno Maulide
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：October 4, 2016
- 年：2016
- 卷：55
- 期：41
- 页码：12864-12867
- 全文大小：1555K
- ISSN：1521-3773
文摘
The synthesis of pyridines through direct intermolecular cycloaddition of alkynes and nitriles is a contemporary challenge in organic synthesis. A Brønsted acid mediated formal [2+2+2] cycloaddition of heteroalkynes and nitriles was developed that proceeds under mild conditions. This constitutes a modular approach to highly substituted pyridine cores.