Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model
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- 作者：Chao Wang ; Xiaokui Huo ; Xiangge Tian ; Min Xu ; Peipei Dong ; Zhilin Luan ; Xiaobo Wang ; Baojing Zhang ; Bo Zhang ; Shanshan Huang ; Sa Deng and Xiaochi Ma
- 刊名：British Journal of Pharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：173
- 期：22
- 页码：3261-3275
- 全文大小：1516K
- ISSN：1476-5381
文摘
Herbs which are widely used as food and medicine, are involved in many physiopathological processes. Melatonin is a human hormone, synthesized and secreted by the pineal gland, with a range of biological functions. Here, we have evaluated the potential influences of components extracted from common herbs on melatonin metabolism in humans.