Production of Pure Aqueous ¹³C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization

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• 作者：Dr. Kirill V. Kovtunov ; Dr. Danila A. Barskiy ; Dr. Roman V. Shchepin ; Oleg G. Salnikov ; Dr. Igor P. Prosvirin ; Dr. Andrey V. Bukhtiyarov ; Dr. Larisa M. Kovtunova ; Prof. Valerii I. Bukhtiyarov ; Prof. Igor V. Koptyug and Prof. Eduard Y. Chekmenev
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：November 7, 2016
• 年：2016
• 卷：22
• 期：46
• 页码：16446-16449
• 全文大小：786K
• ISSN：1521-3765

文摘

A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce ¹³C-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO₂ catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized ¹³C-enriched ethyl acetate-1-¹³C detected at 9.4 T. An approximately 14-fold ¹³C signal enhancement was detected using circa 50 % parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to ¹³C nuclei. This first observation of ¹³C PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.