The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
详细信息 查看全文
- 作者：Xueting Bai ; Peixuan Yang ; Qiaoling Zhou ; Bozhi Cai ; Manon Buist-Homan ; He Cheng ; Jiyang Jiang ; Daifei Shen ; Lijun Li ; Xiajiong Luo ; Klaas Nico Faber ; Han Moshage and Ganggang Shi
- 刊名：British Journal of Pharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：174
- 期：1
- 页码：41-56
- 全文大小：1092K
- ISSN：1476-5381
文摘
Liver diseases are mostly accompanied by inflammation and hepatocyte death. Therapeutic approaches targeting both hepatocyte injury and inflammation are not available. Natural compounds are considered as potential treatment for inflammatory liver diseases. Hesperetin, a flavonoid component of citrus fruits, has been reported to have anti-inflammatory properties. The aim of this study was to evaluate the cytoprotective and anti-inflammatory properties of hesperetin both in vitro and in models of fulminant hepatitis.