Diagnostic and prognostic value of human prion detection in cerebrospinal fluid

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• 作者：Aaron Foutz ; Brian S. Appleby ; Clive Hamlin ; Xiaoqin Liu ; Sheng Yang ; Yvonne Cohen ; Wei Chen ; Janis Blevins ; Cameron Fausett ; Han Wang ; Pierluigi Gambetti ; Shulin Zhang ; Andrew Hughson ; Curtis Tatsuoka ; Lawrence B. Schonberger ; Mark L. Cohen ; Byron Caughey and Jiri G. Safar
• 刊名：Annals of Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：1
• 页码：79-92
• 全文大小：481K
• ISSN：1531-8249

文摘

Several prion amplification systems have been proposed for detection of prions in cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with second-generation real-time quaking-induced conversion (RT-QuIC). The objective of this study was to investigate the diagnostic performance of the RT-QuIC prion test in the broad phenotypic spectrum of prion diseases.